An important consequence is that meropenem, in contrast to imipenem, can be used for the treatment of bacterial meningitis. Meropenem. Pneumonia is inflammation of the lung usually caused by bacterial or viral infection (rarely, also by fungi) that causes the air sacs to fill with pus. Serious adverse effects are rare. Meropenem is well tolerated with the most common adverse effects being diarrhea, rash, nausea/vomiting, and inflammation at the injection site. and improve treatment outcomes with our comprehensive & structured data on drug adverse effects. â ¢ Body as a Whole : Pain, abdominal pain, chest pain, fever, back pain, abdominal enlargement, chills and pelvic pain. Case report: A 59-year-old male patient developed severe thrombocytopenia 8 days after the administration of meropenem and cefoperazone-sulbactam. Infection is spread generally through contaminated food or drink. The valproic acid concentrations may drop below the therapeutic range as a result of this interaction, therefore increasing the risk of breakthrough seizures. Background: Drug-induced immune thrombocytopenia (DITP) is a serious, life-threatening clinical syndrome, the diagnosis of which is consistently difficult. Common side effects include drug ineffective among females and drug ineffective among males. Case reports in the literature have shown that co-administration of carbapenems, including meropenem, to patients receiving valproic acid or divalproex sodium results in a reduction in valproic acid concentrations. Bacterial Infections 101 Pictures Slideshow, E. coli 0157:H7 (Escherichia coli 0157:H7), E. Coli Outbreaks in Potato Salad and Wading Pool. Safe and effective use of meropenem is not established in pregnant females. hematocrit, decreased white blood cell (WBC), shortened prothrombin time and shortened partial thromboplastin time, Pneumonia is inflammation of the lungs caused by fungi, bacteria, or viruses. Meropenem should be restricted to serious infections where other antibiotics are contra indicated or ineffective. injection 8 hourly Route : IV Onset […] Meropenem and vaborbactam are substantially excreted by the kidney and the risk of adverse reactions may be greater in those with renal impairment. It is given by injection into a vein.. Common side effects include nausea, diarrhea, constipation, headache, rash, and pain at the site of injection. 1. E. coli can cause urinary tract and bladder infections, or lead to sepsis. Visit the FDA MedWatch website or call 1-800-FDA-1088. It is supplied as a white crystalline powder to be dissolved in 5% monobasic potassium phosphate solution. Co-administration of probenecid with meropenem is not recommended. Below is a summary of known side effects for Meropenem … This content does not have an Arabic version. Many different. This content does not have an English version. The carbapenems are beta-lactam antimicrobial agents with an exceptionally broad spectrum of activity. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for meropenem/vaborbactam and any potential adverse effects on the breastfed child from meropenem/vaborbactam or from underlying maternal condition. See additional information. Abdominal pain. Nausea and vomiting. How is meropenem best taken? Serious reactions rarely may occur such as: Serious hypersensitivity (allergic) reactions may occur. Merrem IV prevents bacteria from forming the walls that surround them. Meropenem, sold under the brand names Merrem among others. … ... Meropenem Side Effects. Vomiting Many patients in these trials were severely ill and had multiple background diseases, physiological impairments and were receiving multiple other drug therapies. Worldwide post-marketing adverse reactions not otherwise listed in the Adverse Reactions from Clinical Trials section of this prescribing information and reported as possibly, probably, or definitely drug related are listed within each body system in order of decreasing severity. Possible adverse effects Leukopenia, neutropenia, eosinophillia, thrombocytopenia and anaemia. In repeat dose studies of up to 6 months duration only minor effects were seen including a decrease in red cell parameters in dogs. Take the Pneumonia Quiz on MedicineNet to learn more about this highly contagious, infectious disease. In the Merrem IV treated group, 12/15 patients with seizures had late onset seizures (defined as occurring on day 3 or later) versus 7/20 in the comparator arm. Drug interactions of Merrem IV include valproic acid or divalproex because Merrem IV may reduce absorption of valproic acid and divalproex from the intestine and increase elimination of the drugs through the kidneys thereby reducing the levels of these drugs in the body and reducing their effectiveness. Adverse Effects. It works by stopping the growth of bacteria. Older carbapenems, such as imipenem, were often susceptible to degradation by the enzyme dehydropeptidase-1 (DHP-1) located in renal tubules and required co-administration with a … If it affects one lung, it is termed single pneumonia. The study was open-label, uncontrolled, 98% of the infants received concomitant medications, and … decreasing the serum concentrations of valproic acid. Meningitis, inflammation of the meninges, symptoms and signs include neck stiffness, headache, and fever. Anemia If … Is meropenem injection safe to take if I'm pregnant or breastfeeding? Dose : 0.5-2.0 g (10-40 mg/kg) by slow i.v. However, meropenem should not be used to treat MRSA infections. valproic acid's glucuronide metabolite (VPA-g) back to valproic acid, thus GENERIC NAME(S): Meropenem. These may be encountered; Pain at the site of injection. Side Effects What are the side effects of Meropenem (Merrem)? Schedule your appointment now for safe in-person care. Skin reactions. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer — Mayo Clinic Health Letter, Time running out - 40% off Online Mayo Clinic Diet ends soon. © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). Some of these include meningitis, intra-abdominal infection, pneumonia, sepsis, and anthrax. It is used for treating infections caused by certain bacteria. seizure, nervousness, paresthesia, hallucinations, somnolence, anxiety, Decreased urine output. 33 years experience Hematology and Oncology. If it affects only a certain lobe of a lung it's termed lobar pneumonia. Merrem IV prevents bacteria from forming the walls that surround them. Meropenem is excreted in human breast milk; however, no information is available on the effects of meropenem on the breast-fed child or on milk production. Side Effects for MEROPENEM (injection, powder, for solution) are also known as adverse reactions. Meropenem Vial. mL/min). Mild pneumonia may be healed by body’s defense system. patients with moderately severe renal impairment (creatinine clearance 10 to 26 Consult your doctor before breastfeeding. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you. The following adverse reaction frequencies were derived from the clinical trials in the 2904 … RESULTS: Adverse events were more common with use of meropenem compared with imipenem/cilastatin (62.8/1000 infant days versus 40.7/1000 infant days, P < 0.001). leukocytosis, hypokalemia, Renal: increased creatinine and increased blood urea nitrogen (BUN). has been prescribed for your pet for the treatment of an infection caused by susceptible bacteria because other less expensive antibiotics were not effective or unacceptable because of their adverse effects. Skin reactions. Meropenem, sold under the brandname Merrem among others, is a broad-spectrum antibiotic used to treat a variety of bacterial infections. Mayo Clinic does not endorse companies or products. Merrem IV. Valproic acid: There is evidence that meropenem may reduce serum levels of valproic acid to subtherapeutic levels. Know uses, side effects, dosage, contraindications, substitutes, benefit, interactions, purpose, drug interactions, precautions, warnings … Learn more about Meropenem ... Because of the possibility for adverse reactions in nursing infants from meropenem, a choice should be made whether to stop nursing or to stop use of this medication. Spectrum: Active against the following gram-positive organisms: Staphylococcus aureus, Streptococcus pneumoniae, Viridans group streptococci, Enterococcus faecalis. Our Vabomere (meropenem and vaborbactam) for Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. and animal studies suggest that carbapenems may inhibit the hydrolysis of … Advertising revenue supports our not-for-profit mission. There are many types of E. coli (Escherichia coli). 1 Comparison of data 2 from 4872 patients with a variety of infections (including meningitis) treated with meropenem with that from 4752 patients who received other antibacterials, … Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Because geriatric patients are more likely to have decreased renal function, care should be taken in dose selection, and … You are encouraged to report negative side effects of prescription drugs to the FDA. Enterovirulent Escherichia coli (E. coli) are strains of related bacteria that have a strong propensity to cause gastrointestinal tract infections. The study was open-label, uncontrolled, 98% of the infants received concomitant medications, and the majority of adverse events were reported in neonates less than 32 weeks gestational age and critically ill at baseline, making it difficult to assess the relationship of the adverse events to Local adverse events that were reported with Merrem IV were as follows: Systemic adverse events that were reported with Merrem IV occurring in greater than 1.0% of the patients were. Safe and effective use of Merrem IV is not established in pregnant females. Merrem IV (meropenem injection) is a carbapenem antibiotic used to treat a variety of bacteria. Increased levels of Merrem IV in the body could increase side effects like nausea, vomiting, and headache. Increased levels of meropenem in the body could increase side effects like nausea, vomiting, and headache. Meropenem is a broad-spectrum carbapenem antibiotic. Because geriatric patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function. E coli O157:H7 (EHEC) causes bloody diarrhea and colitis. species. Effects on the nervous system. The following are discussed in greater detail in other sections of labeling: Because clinical trials are conducted under widely varying conditions, adverse reactions rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. E. coli is an infection found worldwide. Dr. Herbert Duvivier answered. Side effects are reported by people who take Meropenem. Schedule your appointment now for safe in-person care. Hornik CP(1), Herring AH, Benjamin DK Jr, Capparelli EV, Kearns GL, van den Anker J, Cohen-Wolkowiez M, Clark RH, Smith PB; Best Pharmaceuticals for Children Act-Pediatric Trials Network. bloating or swelling of the face, arms, hands, lower legs, or feet, burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings, diarrhea (watery and severe), which may also be bloody, unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness, vomiting of blood or material that looks like coffee grounds, white patches in the mouth, tongue, or throat, blistering, peeling, or loosening of the skin, holding false beliefs that cannot be changed by fact, large, hive-like swelling on the face, eyelids, tongue, throat, hands, legs, feet, or genitals, red skin lesions, often with a purple center, seeing, hearing, or feeling things that are not there, sores, ulcers, or white spots in the mouth or on the lips, unusual excitement, nervousness, or restlessness, redness and swelling at the injection site, redness, swelling, or soreness of the tongue, excess air or gas in the stomach or bowels. Symptoms include fever, headache, and a stiff neck. Merrem IV is effective against susceptible strains of E. coli, H. influenzae, K. pneumoniae, N. meningitidis, P. aeruginosa, and many other bacteria. Drug information provided by: IBM Micromedex. The IV LD50 of meropenem in rodents is greater than 2000 mg/kg. There are five types of meningitis: viral, bacterial, fungal, parasitic, and noninfectious. Antibiotics treat E. coli infection. A Skin Rash 2. Meropenem and vaborbactam are substantially excreted by the kidney and the risk of adverse reactions may be greater in those with renal impairment. The phase IV clinical study is created by eHealthMe based on 18,208 reports from the FDA, and is updated regularly. You could have more side effects. General Description: Meropenem. depression, asthenia, Respiratory: respiratory disorder, dyspnea, pleural effusion, asthma, cough increased, lung edema, Skin and Appendages: urticaria, sweating, skin ulcer, Urogenital System: dysuria, kidney failure, vaginal moniliasis, urinary incontinence. Adverse events associated with meropenem versus imipenem/cilastatin therapy in a large retrospective cohort of hospitalized infants. bradycardia, hypotension, syncope, Digestive System: oral moniliasis, anorexia, cholestatic jaundice/jaundice, flatulence, ileus, hepatic failure, dyspepsia, Pneumonia can be deadly. Probenecid may increase levels of Merrem IV by reducing its elimination through the kidneys. intestinal obstruction, Hemic/Lymphatic: anemia, hypochromic anemia, hypervolemia, Metabolic/Nutritional: peripheral edema, hypoxia, Nervous System: insomnia, agitation, delirium, confusion, dizziness, All rights reserved. water. Meropenem is one of the most commonly used antibacterial agents with relatively few side effects. Merrem IV was studied in 200 neonates and infants less than 3 months of age. In rats administered intravenous meropenem in late pregnancy and during the lactation period, there were no adverse effects on offspring at doses equivalent to approximately 3.2 times the MRHD based on body surface area comparison (see Data). You may report side effects to the FDA at 1-800-FDA-1088. The background risk of major birth defects and miscarriage for the indicated population is unknown. Find patient medical information for meropenem intravenous on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. The following adverse reactions have been identified during post-approval use of Merrem IV. In rats administered intravenous meropenem in late pregnancy and during the lactation period, there were no adverse effects on offspring at doses equivalent to approximately 3.2 times the MRHD based on body surface area comparison (see Data). What are the possible side effects of meropenem? Meropenem resists the actions of many enzymes that degrade most other penicillins and penicillin-like anti-infectives. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for meropenem and any potential adverse effects on the breast-fed child from meropenem or from the underlying maternal conditions. Common adverse effects To compare and contrast imipenem and meropenem in terms of in vitro activity, pharmacokinetics, clinical efficacy and adverse effects. It should be used during pregnancy only if clearly needed. Usually, the goal of medications given for pneumonia is to limit the spread of the disease. Upset stomach, headache, nausea, vomiting, constipation, or diarrhea may also occur. In this report, we present a case of DITP caused by meropenem that was confirmed by laboratory tests. Current literature supports the use of imipenem at a dose of 500 mg every 6 h and meropenem at 1 g every 8 h for the treatment of severe infections. E. coli can cause urinary tract and bladder infections, or lead to sepsis. greater than 0.1% of the patients are listed below within each body system in order of decreasing frequency: Body as a Whole: pain, abdominal pain, chest pain, fever, back pain, abdominal enlargement, chills, pelvic pain, Cardiovascular: heart failure, heart arrest, tachycardia, hypertension, myocardial infarction, pulmonary embolus, Renal Dose : Headache 5. Consult your doctor before breastfeeding. In the seriously ill patient population, it was not possible to determine the relationship between observed adverse events and therapy with Merrem IV. MedicineNet does not provide medical advice, diagnosis or treatment. The types of systemic and local adverse events seen in these patients are similar to the adults, with the most common adverse events reported as possibly, probably, or definitely related to Merrem IV and their rates of occurrence as follows: Pediatric Patients with Bacterial Meningitis. What are the important side effects of Merrem IV (meropenem injection)? Meropenem is generally well tolerated by the central nervous system. Symptoms may vary depending on the strain the individual contracts. Symptoms include severe abdominal pain and bloody diarrhea. Common side effects may include: headache; nausea, vomiting, diarrhea, constipation; rash; or anemia. Case report: A 59-year-old male patient developed severe thrombocytopenia 8 days after the administration of meropenem … Meropenem has proven to be less neurotoxic in animal studies and seems also to be associated with fewer risks for seizures in patients. Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. Merrem IV was studied in 321 pediatric patients (3 months to less than 17 years of age) with meningitis at a dosage of 40 mg/kg every 8 hours. Antibiotics treat pneumonia, and the choice of the antibiotic depends upon the cause of the infection. Check with your doctor or nurse immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Adverse effects Pain at the site of injection. Adverse effects reported in 1% or more of patients receiving meropenem including GI effects (diarrhea, nausea, vomiting, constipation), local reactions (pain and inflammation at injection site, phlebitis/thrombophlebitis), headache, anemia, rash, pruritus, sepsis, apnea, shock, glossitis, and oral candidiasis. The adverse reactions include rashes, headache, thrombocytopenia, altered liver function, nausea and vomiting. Terms of Use. The meropenem group had a statistically higher number of patients with transient elevation of liver enzymes. The effects of Vabomere on nursing infants are unknown. In this report, we present a case of DITP caused by meropenem that was confirmed by laboratory tests. Symptoms and signs include cough, fever, shortness of breath, and chills. What drugs interact with Merrem IV (meropenem injection)? You may report side effects to the FDA at 1-800-FDA-1088. Some of these include meningitis, intra-abdominal infection, pneumonia, sepsis, and anthrax. seizure, nervousness, paresthesia, hallucinations, somnolence, anxiety, Uses. Complicated Skin and Skin Structure Infections Meropenem is generally well tolerated by the central nervous system. Serious side effects of Merrem IV include. failure, kidney failure, seizure and shock reported with Merrem IV, increased in Table 3 provides adverse reactions occurring in 1% or greater of patients receiving VABOMERE in the Phase 3 cUTI trial. This site complies with the HONcode standard for trustworthy health information: verify here. Portions of this document last updated: Feb. 01, 2021. In a study of complicated skin and skin structure infections, the adverse reactions were similar to those listed above. A 40-year-old member asked: adverse effects of interferon? Treatment of meningitis depends upon the cause of the infection and may include antibiotics or antiviral medications. Nausea and vomiting. Meropenem is used to treat various types of bacterial infections. Results from both the FDA Adverse Event Database (FAERS) and adverse events extracted from social media by Druginformer are plotted side-by-side for easy comparison. Diarrhea 4. Meropenem is an antibiotic that is used to treat severe infections of the skin or stomach. It is unknown if Merrem IV enters breast milk. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). Blood And Lymphatic System Disorders: agranulocytosis, neutropenia, and leukopenia; a positive direct or indirect Coombs test, and hemolytic anemia. Merrem IV (meropenem injection) is a carbapenem antibiotic used to treat a variety of bacteria. Carbapenems are not alike when it comes to the risk of neurotoxic adverse reactions. Meropenem Accession Number DB00760 Description. Merrem IV is necessary, then supplemental anti-convulsant therapy should be Most pneumonias are caused by bacteria and viruses, but some pneumonias are caused by inhaling toxic chemicals that damage lung tissue. Reconstitution procedure. Laboratory changes seen in the pediatric studies, including the meningitis studies, were similar to those reported in the adult studies. Meropenem : Uses, Side Effects, Interactions. Pneumonia Vaccination: Who Should Have One? It is active against Gram-positive and Gram-negative bacteria. Pneumonia may be contagious for 2-14 days. Common Adverse Reactions The most frequently reported adverse reactions (3% or greater) in patients receiving VABOMERE in the Phase 3 cUTI trial were headache, phlebitis/infusion site reactions, and diarrhea. It is unknown if Merrem IV enters breast milk. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Serious side effects have been reported with meropenem including the following: hypersensitivity (severe allergic reaction) . You will need to talk about the benefits and risks to you and the baby. Meropenem, sold under the brandname Merrem among others, is a broad-spectrum antibiotic used to treat a variety of bacterial infections. Meropenem : Therapeutic uses, Dosage & Side Effects Meropenem is a newer carbapenem antibiotic which is not hydrolysed by renal peptidase; does not need to be protected by cilastatin. Meningitis is an inflammation of the membrane (meninges) surrounding the brain and spinal cord and is characterized by an abnormal number of white blood cells in the cerebrospinal fluid. If inflammation affects both lungs, the infection is termed double pneumonia. Meropenem - Get up-to-date information on Meropenem side effects, uses, dosage, overdose, pregnancy, alcohol and more. Copyright © 2021 IBM Watson Health. Systemic adverse events that were reported with MERREM IV occurring in greater than 1.0% of the patients were diarrhea (4.8%), nausea/vomiting (3.6%), headache (2.3%), rash (1.9%), sepsis (1.6%), constipation (1.4%), apnea (1.3%), shock (1.2%), and pruritus (1.2%). Safe and effective use of Merrem IV is not established in pregnant females. Constipation 3. Side Effects. Meropenem attains a high concentration in the CSF particularly with inflamed meninges and has a lower incidence of seizures than other Carbapenems (NeoMed). Meropenem must be administered intravenously. Therapeutic Effects: Bactericidal action against susceptible bacteria. Animal studies have indicated that meropenem induces fewer seizures than imipenem-cilastatin and clinical data from the manufacturer have substantiated this. General Description: Meropenem. The carbapenems are beta-lactam antimicrobial agents with an exceptionally broad spectrum of activity. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. There was no difference in seizures with meropenem versus imipenem/cilastatin (adjusted odds ratio 0.96; 95% confidence interval: 0.68, 1.32). Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. fainting. ©1996-2020 MedicineNet, Inc. All rights reserved. has been prescribed for your pet for the treatment of an infection caused by susceptible bacteria because other less expensive antibiotics were not effective or unacceptable because of their adverse effects. It should be used with caution in patients with central nervous system disorders. Adverse effects. Call your doctor for medical advice about side effects. No information is available on the effects of meropenem on the breast-fed child or on milk production. Meropenem. Serious adverse reactions reported with meropenem are rare with an incidence of 1 %. Because geriatric patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function. Meropenem resists the actions of many enzymes that degrade most other penicillins and penicillin-like anti-infectives. Terms of Use. Renal Dose : Other side effects not listed may also occur in some patients. Nausea 6. Meropenem is substantially excreted by the kidney and the risk of adverse reactions may be greater in those with renal impairment. The most common adverse events occurring in greater than 5% of the patients were: Adverse events with an incidence of greater than 1%, and not listed above, include: For patients with varying degrees of renal impairment, the incidence of heart

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